VHH Affinity Resin
VHH Affinity Resin
This affinity resin demonstrates exceptional binding specificity, with selective, targeted recognition of either the CH1 or CH3 constant domain of the immunoglobulin heavy chain. Rationally engineered for high caustic (alkali) stability, it delivers a substantially prolonged operational lifetime compared to conventional unmodified affinity media.
Product Details
VHH (Nanobody) Affinity Chromatography Resin VHH domains, commonly known as Nanobodies®, are naturally occurring single-domain antibodies derived from camelid species (including alpacas, llamas and camels). These antibodies naturally lack light chains and occur natively as heavy-chain-only dimers, making affinity resins based on VHH ligands ideally suited for purification of difficult-to-capture formats including Fc-deleted constructs, engineered Fc variants, and bispecific antibodies. This resin exhibits exceptional target specificity, with selective recognition of either the CH1 or CH3 constant domain of the immunoglobulin heavy chain. Rationally engineered for high caustic (alkali) stability, it delivers a substantially extended operational service life compared to conventional unmodified affinity media.
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